Microbiology and Clinical Research

Pathogenesis and host response

Pathogenesis is the process by which a disease or disorder develops. Pathogenesis can include factors which contribute not only to the onset of the disease or disorder, but also to its progression and maintenance. It occurs because of complex interactions between an infecting pathogen and the immune system. The interaction between infectious agents and the immune system can be divided into several discrete phases that vary depending on the perspective. For the pathogen, this involves inoculation into a receptive host milieu, successful initial infection of 'target' cells and replication in suitable host cells, and for the host, this series of events includes recognition of infection by sentinel host immune cells, amplification of innate immune response and, lastly, adaptive immune responses that eliminate the pathogen.

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